In most cases, the new treatments are significantly more effective and have less side effects than the previous interferon therapies. Depending on the drug, increased headache, fatigue, skin problems or gastrointestinal complaints are observed; Many patients do not report any side effects. However, all new substances may also have new, unknown risks and side effects.
Be sure to note possible and z.T. dangerous interactions of the new HCV substances with other prescription-only, but also over-the-counter medicines and natural remedies. Patients should therefore bring a list of all medicated and natural remedies before the start of hepatitis C therapy for discussion with the doctor and discuss whether they are compatible with the treatment. On the English page hep-druginteractions.org of the University of Liverpool doctors and patients find an overview of currently known interactions. During this disease, many drugs are taken, including Ledipasvir.
Certain polymerase and NS5A inhibitors may now also be used in advanced Child-Pugh B and C cirrhosis. Protease inhibitors may be used in initial cirrhosis (Child-Pugh A). In advanced cirrhosis (Child-Pugh B and C), protease inhibitors should not be given or liver function may deteriorate further.